Top NFL matchups to target for Week 16 betting

Over the years, PFF data scientists have conducted extensive studies to better understand and predict player performance. While many of these foundational works continue to shape discussions and influence analysis, the focus here is on identifying how those insights apply to specific weekly matchups and uncovering opportunities the betting market may have overlooked.

Some bets will align with traditional markets, while others will explore more niche options to ensure we leverage the most suitable markets for a given thesis or angle.

C.J. Stroud takes advantage of the Chiefs defense

Since losing cornerback Jaylen Watson earlier this season, the Chiefs’ pass defense has struggled, particularly in preventing explosive plays. Opposing offenses have attacked Kansas City deep at the fourth-highest rate in the NFL, and the team has allowed the fifth-most explosive passes during that span.