NFL Week 5 Betting: Best early bets before lines move

2Y7EH3W Buffalo Bills quarterback Josh Allen (17) throws a pass during the second half of an NFL football game against the Baltimore Ravens, Sunday, Sept. 29, 2024, in Baltimore. (AP Photo/Terrance Williams)

By Judah Fortgang and Daniel Galper
Posted Sep 30, 2024 8:45 am EDT

• Tampa Bay vs. Atlanta has shootout potential: A quick pace of play and two susceptible defenses could lead to a high-scoring environment.

• Don't discount the Bills after their first loss: Buffalo is still a potent team. Take their moneyline (+102) against the Houston Texans in Week 5.

• Unlock your edge with a PFF+ subscription: Get full access to all our in-season fantasy tools, including weekly rankings, WR/CB matchup charts, weekly projections, the Start-Sit Optimizer and more. Sign up now!

Estimated Reading Time: 2 minutes

NFL Week 4 is nearly a wrap, and betting lines are now available for Week 5. Here are our favorite early spread picks for the slate.

Best Bets

PFF's Best Bets Tool reveals the bets PFF's data and algorithms give the biggest edge to within spread, total, player prop, and moneyline markets.

Available with
NFL Power Rankings

Power Rankings are PFF’s NFL power ratings based on weekly player grades in each facet of play. These power rankings are adjusted based on coach, quarterback and the market each season.

Available with
NFL Scores & Schedule

PFF predictions and real time spread, moneyline and over/under lines for each NFL game.

Available with
NCAA Scores & Schedule

PFF predictions and real time spread, moneyline and over/under lines for each NCAA game.

Available with